45th MAGNIMS Plenary Meeting and Workshop

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Date/Time
Date(s) - 16/04/2026 - 17/04/2026
12:00 am

Location
Paris Brain Institute (Institut du Cerveau, ICM)


45th MAGNIMS Plenary Meeting and Workshop

April 16-17th, 2026

Auditorium of the Paris Brain Institute (Institut du Cerveau, ICM)

 

-Click here to download plenary meeting agenda as a pdf document -

-Click here to download workshop agenda as a pdf document -

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April 16th 2026

12.00 – 13.30: Lunch at Space 1-2, located between Room 1-2 and the auditorium

13.30 – 18.00: MAGNIMS Plenary Meeting

  • Welcome and introduction – B. Stankoff, C. Gasperini, M. Schoonheim, J. Sastre-Garriga
  • MAGNIMS DTA reminders and new DTA framework – M. Schoonheim, J. Sastre-Garriga
  • MAGNIMS Member Survey – G. De Luca 
  • Patho-MAGNIMS – G. De Luca, C. Granziera
  • MAGNIMS/ECTRIMS Fellowships

Newly awarded fellowships

  • Let’s reconnect MS! Lesion-driven network disconnection and remyelination in multiple sclerosis – MAGNIMS/ECTRIMS Fellowship: Mar Barrantes-Cepas (Host: Basel, Home: Amsterdam, 1 year) – MAGNIMS PROJECT #..
  • Brain Age Related Multiple Sclerosis Severity Score (BARMSS): improved prediction of clinical outcomes using MRI – MAGNIMS/ECTRIMS Fellowship: Lonneke Bos (Host: Stockholm, Home: Amsterdam, 1 year) – MAGNIMS PROJECT #..

Ongoing fellowships

  • Phenotyping single-subject cortical similarity networks in multiple sclerosis, neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody disease – MAGNIMS/ECTRIMS Fellowship: Katrin Giglhuber (Host: London, Home: Munich, TUM, 1 year) – MAGNIMS PROJECT #68
  • Assessing the clinical relevance of spinal cord atrophy rates in MS using an automatic registration-based method: a multi-center MAGNIMS project – MAGNIMS/ECTRIMS Fellowship: Alessandro Cruciani (Host: London, Home: Roma, 1 year) – MAGNIMS PROJECT #67
  • Exploring the grey-to-white matter borders in multiple sclerosis: A comprehensive analysis through neuroimaging and histopathology – MAGNIMS/ECTRIMS Fellowship: Mongay-Ochoa Neus (Host: Mainz, Home: Barcelona, 1 year) – MAGNIMS PROJECT #46
  • Identifying multiple sclerosis phenotypes and predicting disability with MRI using machine learning – MAGNIMS/ECTRIMS Fellowship: Alessia Bianchi (Host: Siena, Home: London, 2 years) – MAGNIMS PROJECT #44

 

  • New projects

 

  • Multimodal analysis of structural and functional core default mode network nodes: relationship with clinical profiles in multiple sclerosis – Paola Valsasina, M. Rocca and M. Filippi (Milan) – MAGNIMS PROJECT #XX
  • MS-specific thalamic atrophy charts for individualized monitoring – Jelgerhuis (presented by D. van Nederpelt, Amsterdam) – MAGNIMS PROJECT #XX

 

  • Projects to be updated

 

  • A multicenter study of the clinical relevance of enlarged perivascular spaces (ePVS) in multiple sclerosis (Russell Ouellette, Fredrik Piehl, Tobias Granberg) – MAGNIMS PROJECT #74 
  • Pregnancy-Induced Brain Volume Changes in Women with MS, NMOSD, and MOGAD (Tomas Uher, Matej Kudrna and Manuela Vaneckova) – MAGNIMS PROJECT #73
  • Quantification of global and regional skull thickness and normalized signal intensity of skull bones and the relation with ageing and neurodegeneration using MRI in multiple sclerosis (post-hoc re-analysis of MAGNIMS project #37) (Lonneke Bos, G. Pontillo, D.R. van Nederpelt, E.M.M. Strijbis, O. Ciccarelli, A. Toosy, F. Barkhof, M.M. Schoonheim, P.J.W. Pouwels) – MAGNIMS PROJECT #72
  • Decoding Upper versus Lower Limb Impairment in MS (B. Helmlinger, I. Koubiyr, G. Pontillo, T. Broeders, E. Strijbis, M. Khalil, S. Ropele, C. Enzinger, F. Barkhof, D. Pinter, M. Schoonheim) – MAGNIMS PROJECT #71
  • Assessing the weight of typical lesions in different anatomical locations for the diagnosis of MS (Georgina Arrambide, Wallace Brownlee, Gabriel Bsteh) – MAGNIMS PROJECT #69
  • Standardization and Validation of Paramagnetic Rim Lesion Identification in Multiple Sclerosis Across MAGNIMS Centers (Assunta Dal Bianco, T. Berger, G. Bsteh, L. Haider, S. Hametner, H. Lassmann, P. Rommer, T. Zrzavy, M.A. Rocca, M. Filippi, P. Preziosa) – MAGNIMS PROJECT #65
  • A multicenter study of the prognostic value of juxtacortical paramagnetic rims in MS (Ricardo Galbusera, L. Kappos, C. Granziera) – MAGNIMS PROJECT #59
  • Practical Clinical Predictions: Integrating clinical MRI into prediction of progressive multiple sclerosis (T.A. Fuchs, F. Barkhof, M.M. Schoonheim (Amsterdam) – MAGNIMS PROJECT #58
  • Exploring the Clinical Utility of Quantitative Susceptibility Mapping in Multiple Sclerosis: A Multicenter Study (QSM-MS Study) (Alessandro Cagol, L. Kappos, C. Granziera) – MAGNIMS PROJECT #55
  • Quantitative MRI measures for distinguishing MOGAD from MS white matter lesions and describing white matter lesions remyelination patterns (Valentina Camera, M. Calabrese, J. Palace, R. Geraldes; Verona and Oxford) – MAGNIMS PROJECT #49
  • Impact of disease-modifying treatment initiation on longitudinal changes of choroid plexus volume in patients with multiple sclerosis: a MAGNIMS study (M. Filippi, M.A. Rocca, P. Preziosa, M. Margoni, A. Meani) – MAGNIMS PROJECT #47
  • Prediction of enhancing lesions from non-contrast images using deep learning (Ellis Donders, B. Jasperse, H. Vrenken, F. Barkhof. Amsterdam) – MAGNIMS PROJECT #36
  • MR imaging of the optic nerve: assessment of sensitivity and reproducibility of different MR sequences (A. Rovira, J. Sastre-Garriga, L. Bollo) – MAGNIMS PROJECT #34

 

15.30-16.00 Leg-stretcher break

 

  • Projects not to be updated

 

  • Investigating MRI-based markers of perivascular space–related diffusion properties in MS (post-hoc re-analysis of MAGNIMS fellowship by Gerard-Martí Joan) (Elvira Guzmán, Deborah Pareto, Àlex Rovira, Jaume Sastre-Garriga) – MAGNIMS PROJECT #70
  • Assessment of 2024 McDonald MS criteria – A multicenter prospective study (Luca Bollo, Àlex Rovira, Mar Tintoré, Georgina Àrrambide, Jaume Sastre-Garriga, Cristina Auger, Deborah Pareto, Carmen Espejo, Xavier Montalban) – MAGNIMS PROJECT #66
  • Event-based modelling of microstructural changes of deep brain nuclei and the brainstem in relation to fatigue in MS (Vanessa Wiggermann, M. Madsen, S. Nygaard, H. Lundell, J. Romme Christensen, F. Sellebjerg, H.R. Siebner, F. Barkhof, M. Schoonheim) – MAGNIMS PROJECT #64 
  • A multi-centre validation of T1 dark rim sign in Paramagnetic Rim Lesions (James Grist, Pablo Naval-Baudin, Marco Pisa, Riccardo Nistri, Fulvio Zaccagna, O. Ciccarelli, G. DeLuca)Grey matter in MOGAD: the role of the thalamic-cerebellar pathway (Silvia Messina, J. Palace, G. DeLuca) – MAGNIMS PROJECT #63
  • Grey matter in MOGAD: the role of the thalamic-cerebellar pathway (Silvia Messina, J. Palace, G. DeLuca) – MAGNIMS PROJECT #62
  • Evaluation of effects by autologous stem cell transplantation on paramagnetic rim lesions (Einar August Høgestøl) – MAGNIMS PROJECT #61
  • Evaluating relapse-free disability accumulation in AQP4+NMOSD and MOGAD: Applicability of the PIRA concept and the impact of new lesions and non-motor disabilities (Rosa Cortese, N. De Stefano, O. Ciccarelli) – MAGNIMS PROJECT #60
  • Longitudinal OCT-MRI correlations in MS (LOCuTuS-MRI) – A Multi-Consortium Project (MAGNIMS/IMSVISUAL) (Sara Salama, Sara Collorone, Charmaine Yam, Ferran Prados, Axel Petzold, Olga Ciccarelli, Ahmed Toosy) – MAGNIMS PROJECT #57
  • Diagnosis of relapsing multiple sclerosis in patients with spinal-predominant phenotypes (O. Ciccarelli, W. Brownlee) – MAGNIMS PROJECT #56
  • Uncovering new MS subtypes from structural and functional MRI data: A novel approach using machine learning (ML) on MAGNIMS data stets (A. Gallo; Naples; Fabrizio Esposito) – MAGNIMS PROJECT #52
  • Investigating the relationship between changes in retinal microvascular architecture and brain volumetric changes in multiple sclerosis: a multicentre MAGNIMS study (Charmaine Yam, O. Ciccarelli, D. Sampson, A. Toosy; London) – MAGNIMS PROJECT #51
  • Validation of the electronic frailty index (eFI) using MRI in MS: a multicentre MAGNIMS Study (M. Moccia, O. Ciccarelli; London) – MAGNIMS PROJECT #50
  • Vascular determinants of lesion resolution in NMOSD and MS (J. Palace, R. Geraldes, David Berhanu; Oxford) – MAGNIMS PROJECT #48
  • Uncovering smouldering MS through the integration of biomarkers for chronic activity (S. Llufriu, A. Calvi, E. Martinez-Heras, E. Solana, F. Prados) – MAGNIMS PROJECT #45
  • Age & the risk of a next inflammatory event after a diagnosis of CIS/MS (Eva M.M. Strijbis, M.M. Schoonheim, F. Barkhof, Amsterdam) – MAGNIMS PROJECT #40
  • Quantitative MRI for detection of microstructural alterations in brain and spinal cord of Early MS and NMOSD patients (Matej Kudrna, M Vaneckova, Tomas Uher, Dana Horakova, Michaela Andelova, Jan Krasensky, Prague) – MAGNIMS PROJECT #39

 

  • Publication status

                                                                                                                                 

  • Review papers in writing process
  • MAGNIMS Consensus recommendation on the use of MRI in patients with NMOSD and MOGAD (Rosa Cortese, Nicola de Stefano, Manuela Vaneckova – Workshop Prague, October 2024)
  • Predicting clinical progression in multiple sclerosis: The role of advanced MRI and modelling (Menno Schoonheim, Frederik Barkhof – Workshop Amsterdam, May 2024)
  • Thalamus in MS (C. Enzinger, D. Pinter- Workshop Graz, April 2025)

 

  • Review papers submitted
  • NONE

 

  • Project papers in writing process
  • Normative modelling of brain volumes for clinical MS reporting (Zoe Mendelsohn, O Goodkin, F. Barkhof, F. Prados, London) – Extension of MAGNIMS PROJECT #26
  • Large-scale Assessment of Brain Volume Changes in Healthy Individuals (M. Battaglini, N. De Stefano, Siena) – No MAGNIMS PROJECT number Draft will be circulated by the end of the year
  • Identifying cross-sectional and longitudinal cognitive and brain damage phenotypes in multiple sclerosis using machine learning and MRI techniques – MAGNIMS/ECTRIMS Fellowship: Elisa Colato (Host: Amsterdam, Home: London) – MAGNIMS PROJECT #29
  • Contribution of joined structural/functional MRI damage assessment to characterize MS clinical profiles: a fusion ICA analysis ( Valsasina, M. Rocca, M. Filippi, Milan) – MAGNIMS PROJECT #32
  • Disease progression in patients with MS, MOGAD and AQP4-NMOSD (Rosa Cortese, Marco Battaglini, Nicola De Stefano. Siena) – MAGNIMS PROJECT #38
  • Spatial patterns of grey matter and network alterations related to epilepsy occurrence in patients with multiple sclerosis (Vinzenz Fleischer, Sergiu Groppa, Mainz) – MAGNIMS PROJECT #41
  • Investigating the relationships between paramagnetic rim lesions (PRLs), clinical and MRI measures of disability at different stages of MS: a multi-centre MAGNIMS study – MAGNIMS/ECTRIMS Fellowship: Riccardo Nistri (Host: London, Home: Rome, 1 year) – MAGNIMS PROJECT #43

 

  • Project papers submitted

 

  • Lesion network mapping of fatigue in multiple sclerosis – MAGNIMS/ECTRIMS Fellowship: Mads Madsen (Host: Amsterdam, Home: Copenhagen, 1 year) – MAGNIMS PROJECT #54 – under review in Nature Mental Health
  • Structural connectivity in MS phenotypes: a multicentre study (S. Llufriu) – MAGNIMS Project #20 – Under review in JNNP
  • Non-invasive perfusion patterns (M. Calabrese – Verona) – MAGNIMS PROJECT #21 – Under review in Brain Communications

 

  • Project & Review papers Accepted / Published since last meeting

 

  • Determinants of “age at onset” and cognitive impairment in Multiple Sclerosis: a multi-centric combined analysis of network alterations and cortical damage – MAGNIMS/ECTRIMS Fellowship: Antonia Wenger (Host: Milan, Home: Basel) – MAGNIMS PROJECT #30 – Multiple Sclerosis Journal
  • Brain Age Estimation on T2-FLAIR Scans for Application to Multiple Sclerosis (J. Colman, G. Pontillo, F. Barkhof, J. Cole, O. Ciccarelli, London) – MAGNIMS PROJECT #26 – HBM
  • The role of MRI to assess MS prognosis: what we know and what we need to know (Rome Workshop, September 2021) (C. Gasperini) – Nature Reviews Neurology

Next MAGNIMS meetings:

  • 46th meeting, Oxford – Dates: 19-20 November 2026 – Workshop: TBC
  • 47th meeting, Barcelona – Dates: TBC – Worskhops: TBC

 

20.00 Gala dinner sailing along the Seine

 

45th MAGNIMS Meeting Workshop : « Va vis et deviens : how MS lesions are born, evolve and meet their fate »

Organizers : Benedetta Bodini, Bruno Stankoff, Claudio Gasperini

ICM Auditorium, 17th April 2026

08:00 am – 08:30 am Welcome coffee

 

08:30 am – 08:45 am Introduction

Benedetta Bodini, Bruno Stankoff, Claudio Gasperini

 

08:45 am – 10:00 am Before a lesion is born

Chairs : Matilde Inglese, Menno Schoonheim, Claudio Gasperini

Aletta Vandenbosch, Milan  –  When and why does a pre-lesion become a lesion in the white matter?  15 minutes

Roberta Magliozzi, London  –  When and why does a pre-lesion become a lesion in the grey matter ?  15 minutes

Declan Chard, London  – The long story of a lesion before its appearance : microstructural changes  – 15 minutes

Andrea Lazzarotto, Paris – The long story of a lesion before its appearance : metabolic and perfusion changes – 15 minutes

Discussion – 15 minutes

 

10:00 am-11:00 am The life of a lesion

Chairs: Deborah Pareto, Massimo Filippi, Ahmed Toosy

Gabriele De Luca, Oxford  –  Lesion staging and aging in the brain and the spinal cord : lessons from neuropathology  – 15 minutes

Jaume Sastre-Garriga, Barcelone – Lesion staging and aging: the MRI perspective – 15 minutes

Benedetta Bodini/Bruno Stankoff, Paris – Lesion staging and aging : the positron emission tomography perspective   – 15 minutes

Discussion – 15 minutes

 

11:00 am-11:15 am Coffee break

 

11:15 am-12:45 pm How lesions meet their fate

Chairs : Cristina Granziera, Chris Enzinger, Frederick Barkhof

Mikael Simmons, Munich  – Why do some lesions become chronic active ? 15 minutes

Tobias Granberg, Stockholm  – Uncovering chronic active lesions in the white matter, cortex, and spinal cord – 15 minutes

Paolo Preziosa, Milan  – The determinants of lesion chronic activity : size and topography matter  – 15 minutes

Juliette Dufour/Ilaria Tomasso, Paris  – The determinants of lesion myelin repair : axonal density and energy dysfunction matter  – 15 minutes

Rosanna Cortese, Basel  –  Disappearing lesions in MS and MOGAD  – 15 minutes

Discussion – 15 minutes

 

12:45 pm-13:05 pm Round Table :  Can we predict the fate of a lesion at birth? Defining the data needed to develop clinically actionable tools

Chairs: Mara Rocca, Bruno Stankoff, Nicola De Stefano

 

13:05 pm-13:15 pm Closing remarks

Jaume Sastre-Garriga, Menno Schoonheim

 

13:15 pm-14:30 pm Lunch

 

14:30-16:00 pm Optional visit to the Charcot Library, with access to original clinical notes from Charcot’s multiple sclerosis patients preserved in the archives, including those of Marie-Élisabeth Luc.