Va vis et deviens : how MS lesions are born, evolve and meet their fate

45th MAGNIMS Meeting Workshop : « Va vis et deviens : how MS lesions are born, evolve and meet their fate »

Organizers : Benedetta Bodini, Bruno Stankoff, Claudio Gasperini

ICM Auditorium, 17th April 2026

08:00 am – 08:30 am Welcome coffee

08:30 am – 08:45 am Introduction

Benedetta Bodini, Bruno Stankoff, Claudio Gasperini

08:45 am – 10:00 am Before a lesion is born

Chairs : Matilde Inglese, Menno Schoonheim, Claudio Gasperini

Aletta Vandenbosch, Milan  –  When and why does a pre-lesion become a lesion in the white matter?  15 minutes

Roberta Magliozzi, London  –  When and why does a pre-lesion become a lesion in the grey matter ?  15 minutes

Declan Chard, London  – The long story of a lesion before its appearance : microstructural changes  – 15 minutes

Andrea Lazzarotto, Paris – The long story of a lesion before its appearance : metabolic and perfusion changes – 15 minutes

Discussion – 15 minutes

10:00 am-11:00 am The life of a lesion

Chairs: Deborah Pareto, Massimo Filippi, Ahmed Toosy

Lukas Haider, Vienna  –  Lesion staging and aging in the brain and the spinal cord : lessons from neuropathology  – 15 minutes

Jaume Sastre-Garriga, Barcelone – Lesion staging and aging: the MRI perspective – 15 minutes

Benedetta Bodini/Bruno Stankoff, Paris – Lesion staging and aging : the positron emission tomography perspective   – 15 minutes

Discussion – 15 minutes

11:00 am-11:15 am Coffee break

11:15 am-12:45 pm How lesions meet their fate

Chairs : Cristina Granziera, Chris Enzinger, Frederick Barkhof

Mikael Simmons, Munich  – Why do some lesions become chronic active ? 15 minutes

Tobias Granberg, Stockholm  – Uncovering chronic active lesions in the white matter, cortex, and spinal cord – 15 minutes

Paolo Preziosa, Milan  – The determinants of lesion chronic activity : size and topography matter  – 15 minutes

Juliette Dufour/Ilaria Tomasso, Paris  – The determinants of lesion myelin repair : axonal density and energy dysfunction matter  – 15 minutes

Rosanna Cortese, Basel  –  Disappearing lesions in MS and MOGAD  – 15 minutes

Discussion – 15 minutes

12:45 pm-13:05 pm Round Table :  Can we predict the fate of a lesion at birth? Defining the data needed to develop clinically actionable tools

Chairs: Mara Rocca, Bruno Stankoff, Nicola De Stefano